Targeted therapies for soft tissue sarcomas and desmoid tumors

Soft tissue sarcomas are a group of rare malignant tumors with high recurrence and mortality rate. Little progress has been made in the treatment this pathology over past decades. Surgery or without adjuvant/neoadjuvant radiotherapy is still first-line therapy for localized soft sarcomas, chemotherapy an additional option high-risk patients. However, not all patients advanced metastatic benefit from conventional chemotherapy. characterized by heterogeneity biological behavior variety genetic mutations, which indicates perspective personalized based on tumor histotype, molecular characteristics, new small molecule inhibitors signaling pathways. This article provides overview studies effectiveness targeted most common desmoid tumors.